The Opelousas Museum & Interpretive Center is a great destination for those interested in the civil war, zydeco music, Native American history, or any traveler looking for things to do in Opelousas. The museum explores the history and culture of the Opelousas area from prehistoric times to the present. The Main Exhibit Room tells the story of the Opelousas Indians and the first settlers. The other side of the exhibit space focuses on zydeco, a popular music genre fostered right here in Opelousas. Other exhibits include the Civil War Room, The Geraldine Smith Welch Doll Collection, the Louisiana Video Collection Library, the Rodney Milburn Exhibit, and the Southwest Louisiana Zydeco Music Festival Archives.

Group tours are available by appointment. Sign up to their newsletter or check out their Facebook page for new programming.